That all depends on the LED spot's you are using. Are it DMX LEDPar's? Or normal LED lights from a standard hardware store?

If it are DMX lights you can use a standard DMX interface (like an Enttec DMXUSB pro) 

If it are LED lights form a hardware store you can maybe use a PWM (Puls widht modulator if they are dimmable) or a Relay board to control them. These are also available in dmx versions. 

I think that would be the easiest option.

With kind regards
Gertjan

Izzy supports Artnet out. So if you’d get yourself a device like an Enttec ODE Mk2 or similar, DMXcable and power, you should be good to go. 

If you prefer working with a more dedicated piece of lighting software, you could always use QLC and have Isadora trigger cues through OSC. You’d still need a DMX out device to get the signal to your lights, like the aforementionted Enttec.

Hope this helps

Cheers