Thanks, all.
I did wind up going the OSC route. I haven't touched this material in a while, so it took a bit for my brain to adjust in the darkness.
But, yes:
In Isadora: OSC Transmitter to ETC Eos on the same Mac. Gadget is now outputting correct DMX as tested via a DMX tester. Fabulous!
Final hurdle was switching the OSC transmitter to "on" in Isadora.
Thanks for the support!