I haven't tried ambisonics in Izzy yet, but had a discussion with a colleague and we decided that it is properly possible. We took part in a residency project in a 19-speaker dome studio in Latvia last year. Dirty Deal Audio organised the project, and it's likely that they will be running more residencies: https://www.dda.lv/
Getting experience in a studio that is designed for ambisonics would be a huge help on your journey. The DDA website also has various resources, including tutorials using Sonobus, which should be applicable to the VSTs running in Isadora.