Hi @Woland,
Can you tell us a bit more about resolution you're trying to output on video projectors ?
And what kind of cable and length you are using through projectors ?
It seems it is not a problem coming from Isadora but from kind of frequency and resolution each Bus can manage of the iMac Pro.
As far as I know, Isadora has no problem to manage three outputs at the same time.
You can find more info here :
https://support.apple.com/en-us/HT208366
https://support.apple.com/en-us/HT206587
Second link advices for example to plug the biggest resolution at the very end.
Kind of device and frequency seems to be very important too.
This kind of question went out also when people began using Mac Pro 2013 (the "bin").
6 outputs but, as well as iMac pro, not a Bus dedicated to each output, so you can face bugs depending on which output you're plugging your devices.
I may have time to test projectors on iMac Pro tomorrow , let us know if you found a solution until then.
Best